tina huang data scientist tina huang data scientist

This suggests that genetic links between southern and southwestern European hunter-gatherers around the time of the LGM extended north of the Pyrenees. We also do experiments to test out the features we build and see how users respond to them. Amazing content! No, there are no prerequisites for enrolling. Hunter-gatherers carrying an admixed WHG/EHG genetic profile have been sequenced from various regions of northern and eastern Europe, raising the question of how these two types of ancestries formed and interacted with each other through time and space37,38,39,40. Data science is a lot like cooking. The youngest individual carrying large portions of hunter-gatherer ancestry in the analysed dataset is from Ostorf in northern Germany, dated to around 5.2ka (>90% Oberkassel clusterplus Sidelkino-clustercomponents)(Supplementary Data 3.F). First up is the MIT researcher and YouTuber Jordan Harrod. Fu, Q. et al. Cambridge Archaeol. The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis occurs. A similar pattern is observed through the analysis of ROH segments (Extended Data Fig. Olalde, I. Jodie Sweetin. Ancient Rome: A genetic crossroads of Europe and the Mediterranean. Tina is a computer science student at Stanford University. The oldest individual in the Fournol cluster is Ormesson 2988 from northeastern France (31ka, Early/Middle Gravettian), whereasa Gravettian group from Goyet in Belgium (27ka, Late Gravettian) is found to be a mixture between the Vstonice and Fournol clusters. 803147-RESOLUTION (to S.T. H. Rougier received support from the College of Social and Behavioral Sciences of CSUN and the CSUN Competition for RSCA Awards. Is a data scientist at one of the world's largest tech companies (she keeps the firm anonymous so she can publish more freely). Nature 570, 182188 (2019). ), no. Proc. The incoming Villabruna ancestry later became the most widespread hunter-gatherer ancestry across Europe. Newsletter, Admixture graphs were reconstructed using qpGraph 6450, with allsnps mode to correct for low-coverage sample and Mbuti.DG set as the outgroup. On top of that, its full of useful career and productivity advice, so you can find out what knowledge you need to become a data scientist as well as how to break into the field. 1999 - 20001 year. Taiwan. Product development is, by far, my favorite data science use case for two main reasons. And if youre new to data science, check out the 365 Intro to Data and Data Science course. Highly Influential Citations 3. A total of 23 patients that had operations in a . Le palolithique suprieur en Italie. I love learning new things a. Therefore, the broader terms archaeological culture or simply culture are used here to refer to archaeologically defined material cultures without implying links to modern anthropological and/or ethnographical concepts of culture. It is generated automatically, and you can download, view, and share it at any time. The population history of northeastern Siberia since the Pleistocene. PubMed Biol. 2022 Fab Business Solutions - All Rights Reserved. It will provide you with confidence and methodology for demonstrating the required skills appropriately. Ringbauer, H., Novembre, J. Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. Each aDNA library was double indexed60 in 14 parallel 100l reactions using PfuTurbo DNA Polymerase (Agilent). Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. Interviewed Taiwanese designers and analyzed the interview data. Article First Name Tina #39. It was awesome seeing the thought process behind each of the questions - it helps students immensely! What is Marimekko Chart in Data Visualization? a, MDS plot of pre-LGM individuals. The aligned sequences of all individuals with new genomic data reported in this study are available at the European Nucleotide Archive (ENA) under study accession number PRJEB51862. Adv. In her journey of eventually. After DNA lysis, a subset of samples was extracted using silica-coated magnetic particles on an automated liquid handling system (Agilent Technologies Bravo NGS Workstation)57. This is one of the things that make us stand out from other platforms which usually consider mathematics and statistics a prerequisite. The detailed grouping of individuals shown with empty coloured circles is described in Supplementary Data 1.I. Open access funding provided by Max Planck Society. ScienceDaily. Publication: Huang T, Reimand J. Network-rewiring mutation in kinase signaling networks are informative of cancer patient. Nat. This article reviews qualitative and quantitative studies related to the academic achievement of youth from immigrant Chinese families. Folding bicycle. TV Actresses. Follow a proven methodology, discover how to avoid common mistakes and impress employers as the best person for the job. Tina Huangis a data scientist currently working at a large FAANG enterprise. Philos. However, additional genomes intermediate in time and space are needed to assess whether those two admixture events were independent or part of a common demographic process. 3, 765771 (2019). This is in sharp contrast to the genetic history of Iberian hunter-gatherers, where the spread of the Villabruna/Oberkassel ancestry involved multiple local admixture events with groups carrying high proportions of GoyetQ2 ancestry14 (Fig. Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments. Dotted lines delimit geographic regions described in the text. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. Teaching Assistant. Sci. Lead Advisor - Data Science. Tina Huang hellotinah@gmail.com | 123-456-7890 | 1 BeepbeepBoop St. Philadelphia, PA 19104 EDUCATION AND HONORS University of Data warehousing is a relatively new field that focuses on the use of large datasets for analytical purposes. Posth, C., Yu, H., Ghalichi, A. et al. Nature 534, 200205 (2016). Survival of Late Pleistocene hunter-gatherer ancestry in the Iberian Peninsula. The Villabruna ancestry later appeared in central Europe and it is thought to have largely replaced groups related to the GoyetQ2ancestry4. Patterson, N. et al. Internet Explorer). Pleistocene mitochondrial genomes suggest a single major dispersal of non-Africans and a Late Glacial Population turnover in Europe. Genome-wide patterns of selection in 230 ancient Eurasians. The authors declare no competing interests. 5b and Supplementary Figs. Late Upper Palaeolithic hunter-gatherers in the Central Mediterranean: new archaeological and genetic data from the Late Epigravettian burial Oriente C (Favignana, Sicily). 1, Extended Data Table 1, Supplementary Data 1.A, Supplementary Information, section1 and Supplementary Fig. Radiocarbon 62, 725757 (2020). About the author: Tina Huang is a data scientist at one of the FAANG companies. In addition to this general data science content, Tina teaches SQL . From AI YouTubers to accessibilityadvocates. Rep. 10, 21931 (2020). A recent bottleneck of Y chromosome diversity coincides with a global change in culture. These models are easy to implement as well as really helpful in deciding what to build and how much to invest in it. Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia. Adv. Genome of Petera Muierii skull shows high diversity and low mutational load in pre-glacial Europe. 4 and Supplementary Data 3.C). This is . 9, 442 (2018). Max Planck Institute for Evolutionary Anthropology. K.N., V.V.-M., R.R., T. Ferraz, R.T., D.G.D., M.L., A. Modi, S. Vai, T. Saupe, C.L.S., G. Catalano, L. Pagani, D.C. and E.A. Meyer, M. et al. The newly generated genotypes were merged with 240 published ancient hunter-gatherer genomes and modern worldwide populations for downstream analyses (Supplementary Data 1.G). The PCA was carried out by smartpca in EIGENSOFT 6.0.1102, with modern individuals used for calculation and all the ancient individuals projected on the calculated PCs. Previous studies identified two different genetic compositions in Magdalenian-associated individualsthe GoyetQ2 cluster including central-western European genomes dated to around 15ka (from France, Belgium and Germany), and the ancestry of the El Mirn individual from Spain4,14 from around 19ka. Her YouTube channel advises data science jobs, self-study, boosting productivity, resume reviews, etc. In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a . Biol. de Lige, 2021). Details are provided in Data S2.B. Her first stepping stone into data science was being a research assistant in Bioinformatics. Jones, E. R. et al. The oldest genomes carrying ancestries that derive primarily from the lineage leading to present-day Europeans are Kostenki 14 (from 37ka, with uncertain archaeological association from western Russia), Goyet Q116-1 (35ka, Aurignacian-associated from Belgium) and Bacho Kiro 1653 (35ka, probably Aurignacian-associated from Bulgaria)2,4,8. The black-outlined diamond marked out in the Gravettian group shows the PMR between the two Gravettian-associated individuals from southern Italy (Paglicci 12 and Ostuni 1). 1 MtDNA and Y-chromosome phylogenies. ISSN 1476-4687 (online) Details of the modelling are provided in Supplementary Data 3.E,F. First, I like it because of how powerful (almost magical) it is in driving decisions. This results in a tree with 57 newly reported and previously published ancient individuals while present-day sequences are collapsed in the major Y-chromosome haplogroups (the most basal lineages are not shown). Surprisingly, however, none of those pre-40ka individuals left substantial traces in the genetic makeup of present-day Eurasian populations1,2,6,7. & Hlie, J. F. Temperature and precipitation regime in LGM human refugia of southwestern Europe inferred from 13C and 18O of large mammal remains. has received funding from the Van de Kamp fonds. The purified products were amplified in multiple 100l reactions using Herculase II Fusion DNA Polymerase (Agilent) following the manufacturers specifications with 0.3M of the IS5/IS6 primers. Known to have been the coldest phase of the last Ice Age, the LGM is considered to have caused a demographic decline in large parts of Europe10, with populations retracting to southern latitudes as attestedfor exampleby the contemporaneity of the Solutrean culture (2419ka) in the Iberian peninsula and southern France. In conclusion, our study reveals that western and southwestern Europe served as climatic refugia for the persistence of human groups during the coldest phase of the last Ice Age whereas populations in the Italian peninsula and the eastern European plain were genetically overturned, challenging the role of these regions as glacial refugia for humans. Hi! 27, 21852193.e6 (2017). Science 363, 12301234 (2019). Lifetime access to all course materials and updates. Chintalapati, M., Patterson, N. & Moorjani, P. The spatiotemporal patterns of major human admixture events during the European Holocene. Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers. In particular, the model achieves 96.21% for the validation and 96.47% for testing using the news aggregator data. The neighbour-joining tree was then reconstructed using the neighbour-joining method implemented in Ape 5.3 package104 of R 3.5.1. If you want to know more, you can always go to MySQLs data warehouse site. 5). is supported by a Ramn y Cajal fellowship (RYC-2017-22558). Our results show that the contact zone and the admixture patterns betweenthe Oberkassel and Sidelkino ancestries changed over time (Fig. Our limited-time offer covers individual course purchases only. We report 47 new radiocarbon dates performed on skeletal elements of 40 individuals by the Curt-Engelhorn-Zentrum Archaeometrie in Mannheim (MAMS, n=29), Center for Isotope Research, University of Groningen (GrA and GrM, n=5), University of Aarhus (AAR, n=3), Beta Analytics (Beta, n=2), Zrich (ETH, n=3), International Chemical Analysis (ICA, n=2), Natural History Museum in Paris (Echo Lab, n=1) and Vilnius (FTMC, n=2) (Supplementary Data 1.A). F4-statistics further support this view, revealing that Le Piage II is more closely related to the Fournol clusterthan the Vstonice cluster (f4(Mbuti, Le Piage II; Vstonice, Fournol 85)0, Z=6.58). 26, 827833 (2016). 10, 1218 (2019). Quat. The 10 mock interviews provide a great detailed approach to solving any SQL questions. Gravettian cranial morphology and human group affinities during the European Upper Palaeolithic. Individuals from northwestern Italy (Arene Candide 16), central Italy (Continenza) and Sicily fall on a phylogenetically more derived branch (group 2), which further diversified into a branch composed of Sicilian hunter-gatherers only (group 3). Sci. Commun. 71, 465492 (2015). By co-analysing previously published data with our newly reported genomes associated with the Magdalenian from La Marche (18ka) and Pincevent (15ka) in western and northern France, respectively, and Maszycka (1816ka) in southern Poland, we confirm that the Goyet Q116-1 ancestry survived in all studied Magdalenian-associated genomes besides in Gravettian and Solutrean-associated individuals from southwestern and western Europe (Fig. 1c). 3,528. performed mortuary practices analyses. "Further interdisciplinary research will clarify which exact processes were responsible for the genetic replacements of entire Ice Age populations.". The single-stranded library of Cuiry Les Chaudardes 1 was produced with partial UDG treatment (ss_halfUDG)62 (Supplementary Data 1.B). Details of the modelling are provided in Supplementary Data 3.C. a, Geographic locations of newly reported individuals (filled symbols with black outline) and representative previously published individuals (outlined stars). and T. Saupe received support from the European Union through the European Regional Development Fund (project no. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Schubert, M., Lindgreen, S. & Orlando, L. AdapterRemoval v2: rapid adapter trimming, identification, and read merging. Think about some of your favorite apps today: Instagram, Uber, Facebook, and YouTube. 9 posts. What is a Scatterplot in Data Visualization, Machine Learning in R: Building a Classification Model. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. The libraries underwent shallow shotgun sequencing on an Illumina HiSeq 4000 instrument with 75 single-end-run cycles using the manufacturers protocol, to evaluate the human endogenous DNA content and quality. Us Too. Bioinformatics 20, 289290 (2004). 8 Changes of Sidelkino and Oberkassel ancestry proportions in post-14 ka hunter-gatherers. Instead, for the two SNPs associated with skin colour (SLC24A5 (rs1426654) and SLC45A2 (rs16891982)), Sidelkino clusterand Ukraine HG groups show a higher frequency (>90% for SLC24A5 and 2961% for SLC45A2) of the derived alleles related to light skin colour, compared with Oberkassel and Villabruna clusters, where those alleles are almost completely absent (<1%). Error bars show 1s.e.m. The suspension was then centrifuged and transferred into a binding buffer as previously described56. Tina has an MSc in Computer Science from the University of Pennsylvania, and an HBSc in Pharmacology from the University of Toronto. I think its cool to see a project like this happen and I hope its interesting for people to learn more about how this stuff works. Djindjian, F. Territories and economies of hunter-gatherer groups during the last glacial maximum in Europe. Charlton, S. et al. "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. Rev. A deft hand at turning dense and complicated topics into informative and entertaining videos, theres a ton to learn from every single video.